Tau is not necessary for amyloid-β–induced synaptic and memory impairments

The amyloid hypothesis posits that the amyloid-beta (Aβ) protein precedes and requires microtubule-associated protein tau in a sort of trigger-bullet mechanism leading to Alzheimer’s disease (AD) pathology. This sequence of events has become dogmatic in the AD field and is used to explain clinical t...

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Detalhes bibliográficos
Publicado no:J Clin Invest
Main Authors: Puzzo, Daniela, Argyrousi, Elentina K., Staniszewski, Agnieszka, Zhang, Hong, Calcagno, Elisa, Zuccarello, Elisa, Acquarone, Erica, Fa’, Mauro, Li Puma, Domenica D., Grassi, Claudio, D’Adamio, Luciano, Kanaan, Nicholas M., Fraser, Paul E., Arancio, Ottavio
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Clinical Investigation 2020
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7456211/
https://ncbi.nlm.nih.gov/pubmed/32544084
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI137040
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