Amphipathic α-Helix AH2 Is a Major Determinant for the Oligomerization of Hepatitis C Virus Nonstructural Protein 4B

Nonstructural protein 4B (NS4B) is a key organizer of hepatitis C virus (HCV) replication complex formation. It induces a specific membrane rearrangement, designated membranous web, that serves as a scaffold for the HCV replication complex. However, the mechanisms underlying membranous web formation...

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Bibliographic Details
Main Authors: Gouttenoire, Jérôme, Roingeard, Philippe, Penin, François, Moradpour, Darius
Format: Artigo
Language:Inglês
Published: American Society for Microbiology (ASM) 2010
Subjects:
Structure and Assembly
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3004355/
https://ncbi.nlm.nih.gov/pubmed/20926561
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.01798-10
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