Aminoterminal Amphipathic α-Helix AH1 of Hepatitis C Virus Nonstructural Protein 4B Possesses a Dual Role in RNA Replication and Virus Production

Nonstructural protein 4B (NS4B) is a key organizer of hepatitis C virus (HCV) replication complex formation. In concert with other nonstructural proteins, it induces a specific membrane rearrangement, designated as membranous web, which serves as a scaffold for the HCV replicase. The N-terminal part...

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Detalhes bibliográficos
Publicado no:PLoS Pathog
Main Authors: Gouttenoire, Jérôme, Montserret, Roland, Paul, David, Castillo, Rosa, Meister, Simon, Bartenschlager, Ralf, Penin, François, Moradpour, Darius
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2014
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4231108/
https://ncbi.nlm.nih.gov/pubmed/25392992
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.ppat.1004501
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