Hepatitis C Virus RNA Replication Requires a Conserved Structural Motif within the Transmembrane Domain of the NS5B RNA-Dependent RNA Polymerase

Hepatitis C virus (HCV) nonstructural protein 5B (NS5B), the viral RNA-dependent RNA polymerase (RdRp), is a tail-anchored protein with a highly conserved C-terminal transmembrane domain (TMD) that is required for the assembly of a functional replication complex. Here, we report that the TMD of the...

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Detalhes bibliográficos
Main Authors: Brass, Volker, Gouttenoire, Jérôme, Wahl, Anja, Pal, Zsuzsanna, Blum, Hubert E., Penin, François, Moradpour, Darius
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology (ASM) 2010
Assuntos:
Structure and Assembly
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2953178/
https://ncbi.nlm.nih.gov/pubmed/20739529
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.01519-10
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