Membrane Association of the RNA-Dependent RNA Polymerase Is Essential for Hepatitis C Virus RNA Replication

The hepatitis C virus (HCV) RNA-dependent RNA polymerase (RdRp), represented by nonstructural protein 5B (NS5B), belongs to a class of integral membrane proteins termed tail-anchored proteins. Its membrane association is mediated by the C-terminal 21 amino acid residues, which are dispensable for Rd...

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Bibliografiska uppgifter
Huvudupphovsmän: Moradpour, Darius, Brass, Volker, Bieck, Elke, Friebe, Peter, Gosert, Rainer, Blum, Hubert E., Bartenschlager, Ralf, Penin, François, Lohmann, Volker
Materialtyp: Artigo
Språk:Inglês
Publicerad: American Society for Microbiology 2004
Ämnen:
Replication
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC524999/
https://ncbi.nlm.nih.gov/pubmed/15542678
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.78.23.13278-13284.2004
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