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Rapid isolation of high affinity human antibodies against the tumor vascular marker Endosialin/TEM1, using a paired yeast display/secretory scFv library platform
Endosialin/TEM1 is predominantly expressed on neovasculature, thus ideally suited for diagnostic, targeted-imaging and -therapy of cancer. To isolate TEM1-specific affinity reagents, we thought to screen a recombinant antibody (scFv) library derived from the repertoire of a patient with thrombotic t...
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| Main Authors: | , , , , , |
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| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
2010
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3003766/ https://ncbi.nlm.nih.gov/pubmed/20837020 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jim.2010.09.001 |
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