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Broad Spectrum Antibiotic Activity of the Arylomycin Natural Products is Masked by Natural Target Mutations
Novel classes of broad-spectrum antibiotics are needed to treat multidrug resistant pathogens. The arylomycin class of natural products inhibits a promising antimicrobial target, type I signal peptidase (SPase), but upon initial characterization appeared to lack whole cell activity against most path...
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| Main Authors: | , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2010
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3003444/ https://ncbi.nlm.nih.gov/pubmed/21095572 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.chembiol.2010.09.009 |
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