Local Sequence Targeting in the AID/APOBEC Family Differentially Impacts Retroviral Restriction and Antibody Diversification

Nucleic acid cytidine deaminases of the activation-induced deaminase (AID)/APOBEC family are critical players in active and innate immune responses, playing roles as target-directed, purposeful mutators. AID specifically deaminates the host immunoglobulin (Ig) locus to evolve antibody specificity, w...

ver descrição completa

Na minha lista:
Detalhes bibliográficos
Main Authors: Kohli, Rahul M., Maul, Robert W., Guminski, Amy F., McClure, Rhonda L., Gajula, Kiran S., Saribasak, Huseyin, McMahon, Moira A., Siliciano, Robert F., Gearhart, Patricia J., Stivers, James T.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2010
Assuntos:
Enzymology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3003395/
https://ncbi.nlm.nih.gov/pubmed/20929867
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M110.177402
Tags: Adicionar Tag
Sem tags, seja o primeiro a adicionar uma tag!

Registos relacionados