Local Sequence Targeting in the AID/APOBEC Family Differentially Impacts Retroviral Restriction and Antibody Diversification

Nucleic acid cytidine deaminases of the activation-induced deaminase (AID)/APOBEC family are critical players in active and innate immune responses, playing roles as target-directed, purposeful mutators. AID specifically deaminates the host immunoglobulin (Ig) locus to evolve antibody specificity, w...

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Autori principali: Kohli, Rahul M., Maul, Robert W., Guminski, Amy F., McClure, Rhonda L., Gajula, Kiran S., Saribasak, Huseyin, McMahon, Moira A., Siliciano, Robert F., Gearhart, Patricia J., Stivers, James T.
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Society for Biochemistry and Molecular Biology 2010
Soggetti:
Enzymology
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3003395/
https://ncbi.nlm.nih.gov/pubmed/20929867
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M110.177402
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