Neural sirtuin 6 (Sirt6) ablation attenuates somatic growth and causes obesity

In yeast, Sir2 family proteins (sirtuins) regulate gene silencing, recombination, DNA repair, and aging via histone deacetylation. Most of the seven mammalian sirtuins (Sirt1–Sirt7) have been implicated as NAD(+)-dependent protein deacetylases with targets ranging from transcriptional regulators to...

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Detalhes bibliográficos
Main Authors: Schwer, Bjoern, Schumacher, Bjoern, Lombard, David B., Xiao, Cuiying, Kurtev, Martin V., Gao, Jun, Schneider, Jennifer I., Chai, Hua, Bronson, Roderick T., Tsai, Li-Huei, Deng, Chu-Xia, Alt, Frederick W.
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2010
Assuntos:
Biological Sciences
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3003110/
https://ncbi.nlm.nih.gov/pubmed/21098266
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1016306107
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