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Cation-π interaction regulates ligand-binding affinity and signaling of integrin α(4)β(7)
Integrin α(4)β(7) mediates rolling and firm adhesion of leucocytes, two of the critical steps in leukocyte migration and tissue specific homing. Affinity of α(4)β(7) for ligand is dynamically regulated by three interlinked metal ion-binding sites in β(7)-subunit I domain. In this study, we found tha...
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| Main Authors: | , , , , , |
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| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
National Academy of Sciences
2010
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3003088/ https://ncbi.nlm.nih.gov/pubmed/21098296 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1015487107 |
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