Inhibition of Ras-guanine nucleotide-releasing factor 1 (Ras-GRF1) signaling in the striatum reverts motor symptoms associated with l-dopa–induced dyskinesia

l-dopa–induced dyskinesia (LID) is a common debilitating complication of dopamine replacement therapy in Parkinson's disease. Recent evidence suggests that LID may be linked causally to a hyperactivation of the Ras–ERK signaling cascade in the basal ganglia. We set out to determine whether spec...

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Detalhes bibliográficos
Main Authors: Fasano, Stefania, Bezard, Erwan, D'Antoni, Angela, Francardo, Veronica, Indrigo, Marzia, Qin, Li, Doveró, Sandra, Cerovic, Milica, Cenci, M. Angela, Brambilla, Riccardo
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2010
Assuntos:
Biological Sciences
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3003069/
https://ncbi.nlm.nih.gov/pubmed/21115823
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1012071107
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