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Relationship between Ca(2+)-affinity and shielding of bulk water in the Ca(2+)-pump from molecular dynamics simulations

The sarcoplasmic reticulum Ca(2+)-ATPase transports two Ca(2+) per ATP hydrolyzed from the cytoplasm to the lumen against a large concentration gradient. During transport, the pump alters the affinity and accessibility for Ca(2+) by rearrangements of transmembrane helices. In this study, all-atom mo...

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Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Prif Awduron: Sugita, Yuji, Ikeguchi, Mitsunori, Toyoshima, Chikashi
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: National Academy of Sciences 2010
Pynciau:
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC3003049/
https://ncbi.nlm.nih.gov/pubmed/21098671
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1015819107
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