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Relationship between Ca(2+)-affinity and shielding of bulk water in the Ca(2+)-pump from molecular dynamics simulations
The sarcoplasmic reticulum Ca(2+)-ATPase transports two Ca(2+) per ATP hydrolyzed from the cytoplasm to the lumen against a large concentration gradient. During transport, the pump alters the affinity and accessibility for Ca(2+) by rearrangements of transmembrane helices. In this study, all-atom mo...
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| Main Authors: | , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
National Academy of Sciences
2010
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3003049/ https://ncbi.nlm.nih.gov/pubmed/21098671 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1015819107 |
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