G protein-coupled receptor kinase 2 and arrestin2 regulate arterial smooth muscle P2Y-purinoceptor signalling

AIMS: Prolonged P2Y-receptor signalling can cause vasoconstriction leading to hypertension, vascular smooth muscle hypertrophy, and hyperplasia. G protein-coupled receptor signalling is negatively regulated by G protein-coupled receptor kinases (GRKs) and arrestin proteins, preventing prolonged or i...

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Detalhes bibliográficos
Main Authors: Morris, Gavin E., Nelson, Carl P., Everitt, Diane, Brighton, Paul J., Standen, Nicholas B., Challiss, R.A. John, Willets, Jonathon M.
Formato: Artigo
Idioma:Inglês
Publicado em: Oxford University Press 2011
Assuntos:
Original Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3002865/
https://ncbi.nlm.nih.gov/pubmed/20705669
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/cvr/cvq249
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