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Intrinsically disordered PEP-19 confers unique dynamic properties to apo and calcium calmodulin

PEP-19 (Purkinje cell protein 4) is an intrinsically disordered protein with an IQ calmodulin (CaM) binding motif. Expression of PEP-19 was recently shown to protect cells from apoptosis and cell death due to Ca(2+) overload. Our initial studies showed that PEP-19 causes novel and dramatic increases...

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Détails bibliographiques
Auteurs principaux: Wang, Xu, Kleerekoper, Quinn K., Xiong, Liang-wen, Putkey, John A.
Format: Artigo
Langue:Inglês
Publié: 2010
Sujets:
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC3001392/
https://ncbi.nlm.nih.gov/pubmed/20973509
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/bi100500m
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