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A dual E3 mechanism for Rub1 ligation to Cdc53
SUMMARY: In ubiquitin-like protein (UBL) cascades, a thioester-linked E2~UBL complex typically interacts with an E3 enzyme for UBL transfer to the target. Here we demonstrate a variant mechanism, whereby the E2 Ubc12 functions with two E3s, Hrt1 and Dcn1, for ligation of the UBL Rub1 to Cdc53’s WHB...
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| Main Authors: | , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2010
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3001161/ https://ncbi.nlm.nih.gov/pubmed/20832729 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molcel.2010.08.030 |
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