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The osmolyte TMAO stabilizes native RNA tertiary structures in the absence of Mg(2+): evidence for a large barrier to folding from phosphate dehydration
The stabilization of RNA tertiary structures by ions is well known, but the neutral osmolyte trimethylamine oxide (TMAO) can also effectively stabilize RNA tertiary structure. To begin to understand the physical basis for the effects of TMAO on RNA, we have quantitated the TMAO-induced stabilization...
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| Main Authors: | , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2010
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3001104/ https://ncbi.nlm.nih.gov/pubmed/20875423 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jmb.2010.09.043 |
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