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The osmolyte TMAO stabilizes native RNA tertiary structures in the absence of Mg(2+): evidence for a large barrier to folding from phosphate dehydration

The stabilization of RNA tertiary structures by ions is well known, but the neutral osmolyte trimethylamine oxide (TMAO) can also effectively stabilize RNA tertiary structure. To begin to understand the physical basis for the effects of TMAO on RNA, we have quantitated the TMAO-induced stabilization...

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Main Authors: Lambert, Dominic, Leipply, Desirae, Draper, David E.
Format: Artigo
Sprog:Inglês
Udgivet: 2010
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3001104/
https://ncbi.nlm.nih.gov/pubmed/20875423
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jmb.2010.09.043
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