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Deep sequencing analysis of mutations resulting from the incorporation of dNTP analogs
Next-generation DNA sequencing technology was used to score >100 000 mutations resulting from exposure of a nucleic acid template to a mutagenic dNTP analog during a single pass of a DNA polymerase. An RNA template of known secondary structure was reverse transcribed in the presence of 8-oxo-dGTP...
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| Hauptverfasser: | , |
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| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
Oxford University Press
2010
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| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3001061/ https://ncbi.nlm.nih.gov/pubmed/20693528 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkq685 |
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