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Ubiquitin Proteasome-dependent Degradation of the Transcriptional Coactivator PGC-1α via the N-terminal Pathway

PGC-1α is a potent, inducible transcriptional coactivator that exerts control on mitochondrial biogenesis and multiple cellular energy metabolic pathways. PGC-1α levels are controlled in a highly dynamic manner reflecting regulation at both transcriptional and post-transcriptional levels. Here, we d...

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Detalles Bibliográficos
Main Authors: Trausch-Azar, Julie, Leone, Teresa C., Kelly, Daniel P., Schwartz, Alan L.
Formato: Artigo
Idioma:Inglês
Publicado: American Society for Biochemistry and Molecular Biology 2010
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Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC3001001/
https://ncbi.nlm.nih.gov/pubmed/20713359
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M110.131615
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