Inhibition of Deoxyhypusine Synthase Enhances Islet β Cell Function and Survival in the Setting of Endoplasmic Reticulum Stress and Type 2 Diabetes

Islet β cell dysfunction resulting from inflammation, ER stress, and oxidative stress is a key determinant in the progression from insulin resistance to type 2 diabetes mellitus. It was recently shown that the enzyme deoxyhypusine synthase (DHS) promotes early cytokine-induced inflammation in the β...

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Hlavní autoři: Robbins, Reiesha D., Tersey, Sarah A., Ogihara, Takeshi, Gupta, Dhananjay, Farb, Thomas B., Ficorilli, James, Bokvist, Krister, Maier, Bernhard, Mirmira, Raghavendra G.
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society for Biochemistry and Molecular Biology 2010
Témata:
Molecular Bases of Disease
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3000976/
https://ncbi.nlm.nih.gov/pubmed/20956533
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M110.170142
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