Regulation of Mitochondrial Glutathione Redox Status and Protein Glutathionylation by Respiratory Substrates

Brain and liver mitochondria isolated by a discontinuous Percoll gradient show an oxidized redox environment, which is reflected by low GSH levels and high GSSG levels and significant glutathionylation of mitochondrial proteins as well as by low NAD(P)H/NAD(P) values. The redox potential of brain mi...

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Bibliographic Details
Main Authors: Garcia, Jerome, Han, Derick, Sancheti, Harsh, Yap, Li-Peng, Kaplowitz, Neil, Cadenas, Enrique
Format: Artigo
Language:Inglês
Published: American Society for Biochemistry and Molecular Biology 2010
Subjects:
Bioenergetics
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3000945/
https://ncbi.nlm.nih.gov/pubmed/20937819
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M110.164160
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