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Muscle Wasting in Aged, Sarcopenic Rats Is Associated with Enhanced Activity of the Ubiquitin Proteasome Pathway
Among the hallmarks of aged organisms are an accumulation of misfolded proteins and a reduction in skeletal muscle mass (“sarcopenia”). We have examined the effects of aging and dietary restriction (which retards many age-related changes) on components of the ubiquitin proteasome system (UPS) in mus...
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| Главные авторы: | , , , , , , , |
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| Формат: | Artigo |
| Язык: | Inglês |
| Опубликовано: |
American Society for Biochemistry and Molecular Biology
2010
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| Предметы: | |
| Online-ссылка: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3000941/ https://ncbi.nlm.nih.gov/pubmed/20940294 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M110.129718 |
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