Muscle Wasting in Aged, Sarcopenic Rats Is Associated with Enhanced Activity of the Ubiquitin Proteasome Pathway

Among the hallmarks of aged organisms are an accumulation of misfolded proteins and a reduction in skeletal muscle mass (“sarcopenia”). We have examined the effects of aging and dietary restriction (which retards many age-related changes) on components of the ubiquitin proteasome system (UPS) in mus...

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Autores principales: Altun, Mikael, Besche, Henrike C., Overkleeft, Herman S., Piccirillo, Rosanna, Edelmann, Mariola J., Kessler, Benedikt M., Goldberg, Alfred L., Ulfhake, Brun
Formato: Artigo
Lenguaje:Inglês
Publicado: American Society for Biochemistry and Molecular Biology 2010
Materias:
Protein Synthesis and Degradation
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC3000941/
https://ncbi.nlm.nih.gov/pubmed/20940294
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M110.129718
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