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Uracil-DNA glycosylase: Structural, thermodynamic and kinetic aspects of lesion search and recognition

Uracil appears in DNA as a result of cytosine deamination and by incorporation from the dUTP pool. As potentially mutagenic and deleterious for cell regulation, uracil must be removed from DNA. The major pathway of its repair is initiated by uracil-DNA glycosylases (UNG), ubiquitously found enzymes...

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Detaylı Bibliyografya
Asıl Yazarlar: Zharkov, Dmitry O., Mechetin, Grigory V., Nevinsky, Georgy A.
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: 2009
Konular:
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC3000906/
https://ncbi.nlm.nih.gov/pubmed/19909758
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.mrfmmm.2009.10.017
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