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Discovery of novel α7 nicotinic receptor antagonists

Two distinct families of small molecules were discovered as novel α7 nicotinic acetylcholine receptor (nAChR) antagonists by pharmacophore-based virtual screening. These novel antagonists exhibited selectivity for the neuronal α7 subtype over other nAChRs and good brain penetration. Neuroprotection...

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Detalhes bibliográficos
Main Authors: Peng, Youyi, Zhang, Qiang, Snyder, Gretchen L., Zhu, Hongwen, Yao, Wei, Tomesch, John, Papke, Roger L., O'Callaghan, James P., Welsh, William J., Wennogle, Lawrence P.
Formato: Artigo
Idioma:Inglês
Publicado em: 2010
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3000800/
https://ncbi.nlm.nih.gov/pubmed/20638843
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bmcl.2010.06.103
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