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Discovery of novel α7 nicotinic receptor antagonists
Two distinct families of small molecules were discovered as novel α7 nicotinic acetylcholine receptor (nAChR) antagonists by pharmacophore-based virtual screening. These novel antagonists exhibited selectivity for the neuronal α7 subtype over other nAChRs and good brain penetration. Neuroprotection...
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| Hoofdauteurs: | , , , , , , , , , |
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| Formaat: | Artigo |
| Taal: | Inglês |
| Gepubliceerd in: |
2010
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| Onderwerpen: | |
| Online toegang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3000800/ https://ncbi.nlm.nih.gov/pubmed/20638843 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bmcl.2010.06.103 |
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