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Assessing genuine parents-offspring trios for genetic association studies

OBJECTIVES: Family-based association tests such as the transmission disequilibrium test (TDT) are dependent on the successful ascertainment of true nuclear family trios. Relationship misspecification inevitably occurs in a proportion of trios collected for genotyping which undetected can lead to a l...

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Main Authors: Teo, Yik Y., Fry, Andrew E., Sanjoaquin, Miguel A., Pederson, Bonnie, Small, Kerrin S., Rockett, Kirk A., Kwiatkowski, Dominic P., Clark, Taane G.
Formato: Artigo
Idioma:Inglês
Publicado: 2008
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Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC3000594/
https://ncbi.nlm.nih.gov/pubmed/18931507
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1159/000164396
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