A Bayesian approach using covariance of single nucleotide polymorphism data to detect differences in linkage disequilibrium patterns between groups of individuals

Motivation: Quantifying differences in linkage disequilibrium (LD) between sub-groups can highlight genetic regions or sites under selection and/or associated with disease, and may have utility in trans-ethnic mapping studies. Results: We present a novel pseudo Bayes factor (PBF) approach that asses...

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Detalhes bibliográficos
Main Authors: Clark, Taane G., Campino, Susana G., Anastasi, Elisa, Auburn, Sarah, Teo, Yik Y., Small, Kerrin, Rockett, Kirk A., Kwiatkowski, Dominic P., Holmes, Christopher C.
Formato: Artigo
Idioma:Inglês
Publicado em: Oxford University Press 2010
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Original Papers
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2916719/
https://ncbi.nlm.nih.gov/pubmed/20554688
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/bioinformatics/btq327
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