THE RET/PTC-3 ONCOGENE ACTIVATES CLASSICAL NF-κB BY STABILIZING NIK

The oncogenic fusion protein RET/PTC3 (RP3) that is expressed in papillary thyroid carcinoma (PTC) and thyroid epithelia in Hashimoto’s thyroiditis activates Nuclear Factor-kappa B (NF-κB) and induces pro-inflammatory gene expression; however, the mechanism of this activation is unknown. To address...

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Bibliographic Details
Main Authors: Neely, Robert J., Brose, Marcia S., Gray, Carolyn M., McCorkell, Kelly A., Leibowitz, Jason M, Ma, Changqing, Rothstein, Jay L., May, Michael J.
Format: Artigo
Language:Inglês
Published: 2010
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3000456/
https://ncbi.nlm.nih.gov/pubmed/20818435
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/onc.2010.396
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