Negative Feedback Regulation of NF-κB-Inducing Kinase is Proteasome-Dependent But Does Not Require Cellular Inhibitors of Apoptosis

Non-canonical NF-κB signaling is controlled by the precise regulation of NF-κB Inducing Kinase (NIK) stability. NIK is constitutively ubiquitylated by cellular inhibitor of apoptosis (cIAP) proteins 1 and 2, leading to its complete proteasomal degradation in resting cells. Following stimulation, cIA...

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Autores principales: Gray, Carolyn M., McCorkell, Kelly A., Chunduru, Srinivas K., McKinlay, Mark A., May, Michael J.
Formato: Artigo
Lenguaje:Inglês
Publicado: 2014
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Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC4107106/
https://ncbi.nlm.nih.gov/pubmed/24942881
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bbrc.2014.05.122
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