Noisy Splicing Drives mRNA Isoform Diversity in Human Cells

While the majority of multiexonic human genes show some evidence of alternative splicing, it is unclear what fraction of observed splice forms is functionally relevant. In this study, we examine the extent of alternative splicing in human cells using deep RNA sequencing and de novo identification of...

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Bibliografiske detaljer
Main Authors: Pickrell, Joseph K., Pai, Athma A., Gilad, Yoav, Pritchard, Jonathan K.
Format: Artigo
Sprog:Inglês
Udgivet: Public Library of Science 2010
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3000347/
https://ncbi.nlm.nih.gov/pubmed/21151575
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pgen.1001236
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