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Comment on “Widespread RNA and DNA sequence differences in the human transcriptome”

Li et al. [1] reported over ten thousand mismatches between mRNA and DNA sequences from the same individuals, which they attributed to previously unrecognized mechanisms of gene regulation. We found that at least 88% of these sequence mismatches can likely be explained by technical artifacts such as...

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Detalhes bibliográficos
Publicado no:Science
Main Authors: Pickrell, Joseph K., Gilad, Yoav, Pritchard, Jonathan K.
Formato: Artigo
Idioma:Inglês
Publicado em: 2012
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5207799/
https://ncbi.nlm.nih.gov/pubmed/22422963
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/science.1210484
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