Effect of read-mapping biases on detecting allele-specific expression from RNA-sequencing data

Motivation: Next-generation sequencing has become an important tool for genome-wide quantification of DNA and RNA. However, a major technical hurdle lies in the need to map short sequence reads back to their correct locations in a reference genome. Here, we investigate the impact of SNP variation on...

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Hlavní autoři: Degner, Jacob F., Marioni, John C., Pai, Athma A., Pickrell, Joseph K., Nkadori, Everlyne, Gilad, Yoav, Pritchard, Jonathan K.
Médium: Artigo
Jazyk:Inglês
Vydáno: Oxford University Press 2009
Témata:
Original Papers
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC2788925/
https://ncbi.nlm.nih.gov/pubmed/19808877
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/bioinformatics/btp579
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