p53-mediated apoptosis requires inositol hexakisphosphate kinase-2

Inositol pyrophosphates have been implicated in numerous biological processes. Inositol hexakisphosphate kinase-2 (IP6K2), which generates the inositol pyrophosphate, diphosphoinositol pentakisphosphate (IP7), influences apoptotic cell death. The tumor suppressor p53 responds to genotoxic stress by...

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Autori principali: Koldobskiy, Michael A., Chakraborty, Anutosh, Werner, J. Kent, Snowman, Adele M., Juluri, Krishna R., Vandiver, M. Scott, Kim, Seyun, Heletz, Shira, Snyder, Solomon H.
Natura: Artigo
Lingua:Inglês
Pubblicazione: National Academy of Sciences 2010
Soggetti:
Biological Sciences
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3000257/
https://ncbi.nlm.nih.gov/pubmed/21078964
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1015671107
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