A PCSK9-binding antibody that structurally mimics the EGF(A) domain of LDL-receptor reduces LDL cholesterol in vivo1

Proprotein convertase subtilisin-like/kexin type 9 (PCSK9) regulates LDL cholesterol levels by inhibiting LDL receptor (LDLr)-mediated cellular LDL uptake. We have identified a fragment antigen-binding (Fab) 1D05 which binds PCSK9 with nanomolar affinity. The fully human antibody 1D05-IgG2 completel...

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Main Authors: Ni, Yan G., Di Marco, Stefania, Condra, Jon H., Peterson, Laurence B., Wang, Weirong, Wang, Fubao, Pandit, Shilpa, Hammond, Holly A., Rosa, Ray, Cummings, Richard T., Wood, Dana D., Liu, Xiaomei, Bottomley, Matthew J., Shen, Xun, Cubbon, Rose M., Wang, Sheng-ping, Johns, Douglas G., Volpari, Cinzia, Hamuro, Lora, Chin, Jayne, Huang, Lingyi, Zhao, Jing Zhang, Vitelli, Salvatore, Haytko, Peter, Wisniewski, Douglas, Mitnaul, Lyndon J., Sparrow, Carl P., Hubbard, Brian, Carfí, Andrea, Sitlani, Ayesha
Format: Artigo
Language:Inglês
Published: The American Society for Biochemistry and Molecular Biology 2011
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Research Articles
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2999929/
https://ncbi.nlm.nih.gov/pubmed/20959675
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1194/jlr.M011445
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