An Anti-PCSK9 Antibody Reduces LDL-Cholesterol On Top Of A Statin And Suppresses Hepatocyte SREBP-Regulated Genes

Proprotein convertase subtilisin/kexin type 9 (PCSK9) is a promising therapeutic target for treating coronary heart disease. We report a novel antibody 1B20 that binds to PCSK9 with sub-nanomolar affinity and antagonizes PCSK9 function in-vitro. In CETP/LDLR-hemi mice two successive doses of 1B20, a...

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Bibliografiske detaljer
Main Authors: Zhang, Liwen, McCabe, Timothy, Condra, Jon H., Ni, Yan G., Peterson, Laurence B., Wang, Weirong, Strack, Alison M., Wang, Fubao, Pandit, Shilpa, Hammond, Holly, Wood, Dana, Lewis, Dale, Rosa, Ray, Mendoza, Vivienne, Cumiskey, Anne Marie, Johns, Douglas G., Hansen, Barbara C., Shen, Xun, Geoghagen, Neil, Jensen, Kristian, Zhu, Lei, Wietecha, Karol, Wisniewski, Douglas, Huang, Lingyi, Zhao, Jing Zhang, Ernst, Robin, Hampton, Richard, Haytko, Peter, Ansbro, Frances, Chilewski, Shannon, Chin, Jayne, Mitnaul, Lyndon J., Pellacani, Andrea, Sparrow, Carl P., An, Zhiqiang, Strohl, William, Hubbard, Brian, Plump, Andrew S., Blom, Daniel, Sitlani, Ayesha
Format: Artigo
Sprog:Inglês
Udgivet: Ivyspring International Publisher 2012
Fag:
Research Paper
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3282994/
https://ncbi.nlm.nih.gov/pubmed/22355267
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7150/ijbs.3524
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