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Molecular etiology of a dominant form of type III hyperlipoproteinemia caused by R142C substitution in apoE4

We have used adenovirus-mediated gene transfer in apolipoprotein (apo)E(−/−) mice to elucidate the molecular etiology of a dominant form of type III hyperlipoproteinemia (HLP) caused by the R142C substitution in apoE4. It was found that low doses of adenovirus expressing apoE4 cleared cholesterol, w...

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Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Prif Awduron: Vezeridis, Alexander M., Drosatos, Konstantinos, Zannis, Vassilis I.
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: The American Society for Biochemistry and Molecular Biology 2011
Pynciau:
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC2999928/
https://ncbi.nlm.nih.gov/pubmed/20861163
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1194/jlr.M008409
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