Allele-dependent thermodynamic and structural perturbations in ApoE variants associated with the correction of dyslipidemia and formation of spherical ApoE-containing HDL particles

Overexpression of ApoE4[Leu261Ala/Trp264Ala/Phe265Ala] mutant (ApoE4mutC) prevents hypertriglyceridemia and promotes formation of spherical ApoE-containing HDL in apoE(−/−) or apoA-I(−/−) mice. Although, a similar phenotype was observed with ApoE2[Leu261Ala/Trp264Ala/Phe265Ala] (ApoE2mutC), small di...

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Detalhes bibliográficos
Principais autores: Georgiadou, Dimitra, Chroni, Angeliki, Drosatos, Konstantinos, Kypreos, Kyriakos E., Zannis, Vassilis I., Stratikos, Efstratios
Formato: Artigo
Idioma:Inglês
Publicado em: 2012
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3546125/
https://ncbi.nlm.nih.gov/pubmed/23228878
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.atherosclerosis.2012.11.013
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