Regulation of the Histone H4 Monomethylase PR-Set7 by CRL4(Cdt2) Mediated PCNA Dependent Degradation during DNA Damage

The histone methyltransferase PR-Set7/Set8 is the sole enzyme that catalyzes monomethylation of histone H4 at lysine 20 (H4K20me1). Previous reports document disparate evidence regarding PR-Set7 expression during the cell cycle, the biological relevance of PR-Set7 interaction with PCNA, and its role...

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Hauptverfasser: Oda, Hisanobu, Hübner, Michael R., Beck, David B., Vermeulen, Michiel, Hurwitz, Jerard, Spector, David L., Reinberg, Danny
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2010
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2999913/
https://ncbi.nlm.nih.gov/pubmed/21035370
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molcel.2010.10.011
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