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Beclin 1, an autophagy gene essential for early embryonic development, is a haploinsufficient tumor suppressor
The biochemical properties of beclin 1 suggest a role in two fundamentally important cell biological pathways: autophagy and apoptosis. We show here that beclin 1(-/-) mutant mice die early in embryogenesis and beclin 1(+/-) mutant mice suffer from a high incidence of spontaneous tumors. These tumor...
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| Auteurs principaux: | , , , , |
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| Format: | Artigo |
| Langue: | Inglês |
| Publié: |
National Academy of Sciences
2003
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| Sujets: | |
| Accès en ligne: | https://ncbi.nlm.nih.gov/pmc/articles/PMC299911/ https://ncbi.nlm.nih.gov/pubmed/14657337 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.2436255100 |
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