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Beclin 1, an autophagy gene essential for early embryonic development, is a haploinsufficient tumor suppressor

The biochemical properties of beclin 1 suggest a role in two fundamentally important cell biological pathways: autophagy and apoptosis. We show here that beclin 1(-/-) mutant mice die early in embryogenesis and beclin 1(+/-) mutant mice suffer from a high incidence of spontaneous tumors. These tumor...

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Detaylı Bibliyografya
Asıl Yazarlar: Yue, Zhenyu, Jin, Shengkan, Yang, Chingwen, Levine, Arnold J., Heintz, Nathaniel
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: National Academy of Sciences 2003
Konular:
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC299911/
https://ncbi.nlm.nih.gov/pubmed/14657337
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.2436255100
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