Spinal or systemic TY005, a peptidic opioid agonist/neurokinin 1 antagonist, attenuates pain with reduced tolerance

BACKGROUND AND PURPOSE: The use of opioids in treating pain is limited due to significant side effects including somnolence, constipation, analgesic tolerance, addiction and respiratory depression. Pre-clinical studies have shown that neurokinin 1 (NK(1)) receptor antagonists block opioid-induced an...

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Detalhes bibliográficos
Main Authors: Largent-Milnes, TM, Yamamoto, T, Nair, P, Moulton, JW, Hruby, VJ, Lai, J, Porreca, F, Vanderah, TW
Formato: Artigo
Idioma:Inglês
Publicado em: Blackwell Publishing Ltd 2010
Assuntos:
Research Papers
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2998681/
https://ncbi.nlm.nih.gov/pubmed/20977451
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/j.1476-5381.2010.00824.x
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