Discovery of Novel Multifunctional Ligands with μ/δ Opioid Agonist/Neurokinin-1 (NK1) Antagonist Activities for the Treatment of Pain

Multifunctional ligands with agonist bioactivities at μ/δ opioid receptors (MOR/DOR) and antagonist bioactivity at the neurokinin-1 receptor (NK1R) have been designed and synthesized. These peptide-based ligands are anticipated to produce better biological profiles (e.g., higher analgesic effect wit...

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Vydáno v:J Med Chem
Hlavní autoři: Giri, Aswini Kumar, Apostol, Christopher R., Wang, Yue, Forte, Brittany L., Largent-Milnes, Tally M., Davis, Peg, Rankin, David, Molnar, Gabriella, Olson, Keith M., Porreca, Frank, Vanderah, Todd W., Hruby, Victor J.
Médium: Artigo
Jazyk:Inglês
Vydáno: 2015
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On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5769151/
https://ncbi.nlm.nih.gov/pubmed/26465170
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acs.jmedchem.5b01170
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