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Relation between the Conformational Heterogeneity and Reaction Cycle of Ras: Molecular Simulation of Ras

Ras functions as a molecular switch by cycling between the active GTP-bound state and the inactive GDP-bound state. It is known experimentally that there is another GTP-bound state called state 1. We investigate the conformational changes and fluctuations arising from the difference in the coordinat...

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Библиографические подробности
Главные авторы: Kobayashi, Chigusa, Saito, Shinji
Формат: Artigo
Язык:Inglês
Опубликовано: The Biophysical Society 2010
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Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC2998596/
https://ncbi.nlm.nih.gov/pubmed/21112297
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bpj.2010.09.063
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