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Relation between the Conformational Heterogeneity and Reaction Cycle of Ras: Molecular Simulation of Ras
Ras functions as a molecular switch by cycling between the active GTP-bound state and the inactive GDP-bound state. It is known experimentally that there is another GTP-bound state called state 1. We investigate the conformational changes and fluctuations arising from the difference in the coordinat...
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| Main Authors: | , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado: |
The Biophysical Society
2010
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| Assuntos: | |
| Acceso en liña: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2998596/ https://ncbi.nlm.nih.gov/pubmed/21112297 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bpj.2010.09.063 |
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