Imaging Tetrahymena ribozyme splicing activity in single live mammalian cells
Tetrahymena ribozymes hold promise for repairing genetic disorders but are largely limited by their modest splicing efficiency and low production of final therapeutic proteins. Ribozyme evolution in intact living mammalian cells would greatly facilitate the discovery of new ribozyme variants with hi...
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| Udgivet i: | Proc Natl Acad Sci U S A |
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| Principais autores: | , , , |
| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
National Academy of Sciences
2003
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC299846/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/14645710/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.2036553100 |
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