Domain Swapping in Allosteric Modulation of DNA Specificity

SgrAI is a type IIF restriction endonuclease that cuts an unusually long recognition sequence and exhibits allosteric self-modulation of cleavage activity and sequence specificity. Previous studies have shown that DNA bound dimers of SgrAI oligomerize into an activated form with higher DNA cleavage...

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Detalhes bibliográficos
Main Authors: Park, Chad K., Joshi, Hemant K., Agrawal, Alka, Ghare, M. Imran, Little, Elizabeth J., Dunten, Pete W., Bitinaite, Jurate, Horton, Nancy C.
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2010
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2998434/
https://ncbi.nlm.nih.gov/pubmed/21151881
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pbio.1000554
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