Preparation and crystallization of the Grb7 SH2 domain in complex with the G7-18NATE nonphosphorylated cyclic inhibitor peptide

Grb7 is an adapter protein that is involved in signalling pathways that mediate eukaryotic cell proliferation and migration. Its overexpression in several cancer types has implicated it in cancer progression and led to the development of the G7-18NATE cyclic peptide inhibitor. Here, the preparation...

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Main Authors: Yap, Min Y., Wilce, Matthew C. J., Clayton, Daniel J., Perlmutter, Patrick, Aguilar, Marie-Isabel, Wilce, Jacqueline A.
Format: Artigo
Jezik:Inglês
Izdano: International Union of Crystallography 2010
Teme:
Crystallization Communications
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC2998373/
https://ncbi.nlm.nih.gov/pubmed/21139214
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1107/S1744309110041850
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