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Geminin cooperates with Polycomb to restrain multi-lineage commitment in the early embryo

Transient maintenance of a pluripotent embryonic cell population followed by the onset of multi-lineage commitment is a fundamental aspect of development. However, molecular regulation of this transition is not well characterized in vivo. Here, we demonstrate that the nuclear protein Geminin is requ...

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Detalhes bibliográficos
Main Authors: Lim, Jong-Won, Hummert, Pamela, Mills, Jason C., Kroll, Kristen L.
Formato: Artigo
Idioma:Inglês
Publicado em: Company of Biologists 2011
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2998164/
https://ncbi.nlm.nih.gov/pubmed/21098561
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1242/dev.059824
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